Organic phosphoric acids and derivatives
Apexbio Technology LLC Sitagliptin phosphate monohydrate 654671-77-9 10mM (in 1mL DMSO)
Sitagliptin phosphate monohydrate (CAS 654671-77-9) is a phosphate salt hydrate form of sitagliptin a selective inhibitor of dipeptidyl peptidase-4 (DPP-4) DPP-4 catalyzes the hydrolysis of peptides with proline or alanine residues at their N-terminal ends By inhibiting DPP-4 (IC50 18 nM) without interacting with related enzymes such as DPP-8 and DPP-9 sitagliptin increases circulating levels of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) It is actively explored in studies investigating therapeutic interventions for type 2 diabetes
eMolecules 1150113-66-8 | Ambeed | (1R2R)-N1N2-Bis(2-(bis(35-dimethylphenyl)phosphino)benzyl)cyclohexane-12-diamine | 100mg | 549153065 | A471203 | MFCD17014020 | 775.014 | C52H60N2P2
Ambeed | 4-Bromo-5-chloro-2-methylpyridine | 100mg | 525017800 | A119927 | 1211529-34-8 | MFCD17014484 | 206.470 | C6H5BrClN
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Alkali Scientific Sodium Phosphate Dibasic, Anhydrous, 5 Kg
Sodium Phosphate Dibasic, Anhydrous, 5 Kg is a highly concentrated reagent commonly used to prepare phosphate buffer solutions for laboratory research and applications. The anhydrous form of sodium phosphate dibasic ensures accurate preparation of buffer solutions without the risk of water contamination, which can alter the final concentrations. This reagent is widely used in areas such as chromatography, enzyme assays, molecular biology, and pharmaceutical testing. The 5 Kg quantity is suitable for high-demand laboratories, allowing for efficient buffer preparation for large-scale experiments. It is also a key component in the formulation of many laboratory reagents and chemical processes where pH stability is critical.
Apexbio Technology LLC TAK-632 1228591-30-7 10mM (in 1mL DMSO)
TAK-632 (CAS 1228591-30-7) is a selective inhibitor of RAF kinase isoforms including BRAF CRAF and the mutant BRAF-V600E exhibiting IC50 values of 8 3 nM 1 4 nM and 2 4 nM respectively By targeting the RAF family of serine/threonine kinases TAK-632 disrupts the RAS-RAF-MEK-ERK signaling pathway implicated in MAPK cascade regulation In cellular assays TAK-632 promotes BRAF-CRAF dimerization and demonstrates potent antiproliferative effects in A375 and SK-MEL-2 melanoma cell lines with GI50 values of 6 nM and 11 nM respectively In vivo oral administration in SK-MEL-2 xenograft models inhibits ERK phosphorylation and tumor growth without notable toxicity TAK-632 is suitable for investigating RAF-driven signaling and drug resistance in oncogenic pathway studies
Apexbio Technology LLC KN-92 phosphate 1135280-28-2 10mM (in 1mL DMSO)
KN-92 phosphate is a small-molecule analog of the Ca2 /calmodulin-dependent kinase II (CaMKII) inhibitor KN-93 It is designed as an inactive control compound to distinguish CaMKII-specific effects in experimental settings KN-92 phosphate does not inhibit CaMKII activity and thus serves as a negative control for CaMKII inhibition studies Additionally KN-92 phosphate blocks certain voltage-gated potassium (Kv) channels such as Kv1 2 and Kv1 5 reducing steady-state current amplitudes upon depolarization Based on these pharmacological properties KN-92 phosphate holds research potential in investigating mechanisms underlying CaMKII-related signaling pathways and Kv channel functions
Medchemexpress LLC Pentanedioic acid, 3-oxo-, 1,5-diethyl ester | 105-50-0 | MFCD00009200 | ≥97.0% | 202.21 g/mol | C9H14O5 | 500 G
Diethyl 3-oxopentanedioate is a diethyl ester reagent used in organic synthesis and biochemical research. Supplied as a colorless to light yellow liquid with typical purity ≥97.0%, it serves as a synthetic building block and assay reagent for life-science applications.
- Used as a biochemical reagent and synthetic building block.
- Typical purity ≥97.0%.
- Liquid appearance; density 1.113 g/cm3.
- Molecular weight 202.21 g/mol; formula C9H14O5.
- Available in multiple pack sizes including 500 g.
TARGETMOL CHEMICALS INC FLUDARABINE PHOSPHATE 50MG
Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha ribonucleotide reductase and DNA primase thereby interrupting DNA synthesis and inhibiting tumor cell growth. purity: 99%
Medchemexpress LLC Trimethyl phosphate | 512-56-1 | 98.0% | C3H9O4P | 25 MG
Trimethyl phosphate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
- It is a biochemical reagent.
- It can be used as a biological material.
- It can be used as an organic compound for life science related research.
- It has a purity of 98.0%.
- Its molecular weight is 140.07.
- Its chemical formula is C3H9O4P.
- Its CAS number is 512-56-1.
- It appears as a liquid.
- Its color ranges from colorless to light yellow.
- For storage, keep it at 4°C, sealed, and away from moisture.
- When in solvent, store it at -80°C for 6 months, or -20°C for 1 month (sealed storage, away from moisture).
- It is soluble in DMSO at a concentration of 100 mg/mL (713.93 mM).
Medchemexpress LLC Diethyl 3-oxopentanedioate | 105-50-0 | ≥97.0% | 202.21 g·mol⁻¹ | C9H14O5 | 50 G
Diethyl 3-oxopentanedioate (diethyl acetonedicarboxylate) is an organic biochemical reagent used as a building block in organic synthesis and in biochemical assay development. It is supplied for laboratory research applications.
- High purity (≥97.0%).
- Molecular formula C9H14O5; molecular weight 202.21 g·mol⁻¹.
- Suitable for organic synthesis and biochemical assay development.
- Available in multiple package sizes, including 50 g.
- Solutions available (10 mM in DMSO, 1 mL) for screening workflows.
![eMolecules 7784-09-0 | SILVER PHOSPHATE | AstaTech | MFCD00014148 | 418.574 | Ag3O4P | 95.000 | [Ag+].[Ag+].[Ag+].[O-]P([O-])([O-])=O | 10g | 449770267](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000492254.jpg-250.jpg)
eMolecules 7784-09-0 | SILVER PHOSPHATE | AstaTech | MFCD00014148 | 418.574 | Ag3O4P | 95.000 | [Ag+].[Ag+].[Ag+].[O-]P([O-])([O-])=O | 10g | 449770267
SILVER PHOSPHATE | AstaTech | 7784-09-0 | MFCD00014148 | 418.574 | Ag3O4P | 95.000 | [Ag+].[Ag+].[Ag+].[O-]P([O-])([O-])=O | 10g | 449770267
eMolecules 1246302-31-7 | TERT-BUTYL BIS(2-(1,3-DIOXOISOINDOLIN-2-YL)ETHYL)CARBAMATE | AstaTech | MFCD29067665 | 463.490 | C25H25N3O6 | 95.000 | CC(C)(C)OC(=O)N(CCN1C(=O)c2ccccc2C1=O)CCN1C(=O)c2ccccc2C1=O | 1g | 443836076
TERT-BUTYL BIS(2-(1,3-DIOXOISOINDOLIN-2-YL)ETHYL)CARBAMATE | AstaTech | 1246302-31-7 | MFCD29067665 | 463.490 | C25H25N3O6 | 95.000 | CC(C)(C)OC(=O)N(CCN1C(=O)c2ccccc2C1=O)CCN1C(=O)c2ccccc2C1=O | 1g | 443836076
Apexbio Technology LLC 3PO(Synonyms: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, 3-(3-Pyridyl)-1-(4-pyridyl)-2-propen-1-one), 100mg, CAS: 13309-08-5; 18550-98-6.
3PO (CAS 13309-08-5 18550-98-6) is a small molecule inhibitor targeting 6-phosphofructo-2-kinase (PFKFB3) a regulatory enzyme involved in cellular glucose metabolism Its mode of action involves inhibiting PFKFB3 activity leading to reduced intracellular synthesis of fructose-2 6-bisphosphate and consequently decreased glycolytic flux By perturbing glucose metabolism 3PO modulates cellular proliferation growth and survival pathways The compound is widely used in cell and animal model studies exploring tumor metabolism metabolic disorders and immunometabolism